Salicylic acid excretion. Renal excretion of salicylic acid depends on urinary pH.

Salicylic acid excretion. A small fraction of salicylate is also metabolized to ester or acyl glucuronide, and a further fraction is oxidized to gentisic acid and other metabolites without pharmacological effects. [2] Thus, after salicylate overdose, the major metabolic pathways become saturated and renal excretion of salicylic acid becomes increasingly important. 5 prevents reabsorption of salicylic acid from the urine. Abstract We studied the effects of urinary pH on the kinetics of salicylic acid (SA) with its metabolites and assessed the contribution of alkaline hydrolysis of salicylic acid acyl glucuronide to the renal clearance of salicylic acid. When the urine pH increases from 5 to 8, the renal clearance of salicylate increases 10 to 20 times. [32] Aug 23, 2012 · In contrast, when plasma salicylate concentrations were very high (>700 mg/L), salicylic acid accounted for 65%, while salicyluric acid and the phenolic glucuronide accounted for 22% and 15%, respectively. “The concentration of salicylic acid (SA) in serum provides only limited information concerning the intake of, or exposure to, salicylates, because SA is extensively metabolised and there is considerable interindividual variation in the amounts excreted in urine” Salicylates are primarily eliminated from the body through metabolism in the liver and excretion in the urine. Renal excretion of salicylic acid depends on urinary pH. The concentration of salicylic acid in aspirin powder has been determined by second-derivative UV spectrometry. See full list on wikem. Includes: indications, dosage, adverse reactions and pharmacology. Various studies indicate that In addition, the excretion rate of salicyl glucuronides is affected by the variable excre- tion rate of unchanged salicylic acid, since salicylate excretion and glucuronide synthesis are parallel and therefore competing processes. The greater the urine flow, the more difficult it is to alkalinize the urine. The height of the satellite peak is not altered even in the presence of a large concentration of aspirin. Acetylsalicylic acid is rapidly metabolized to salicylic acid by plasma and gastric esterases. org This "traps " the salicylic acid in the urine where it is excreted, thus greatly enhancing elimination of salicylate from the body. Be cautious of excessive fluid volumes in cases of salicylate-induced pulmonary edema. May 28, 2024 · Forced diuresis is not recommended. Increasing the urine pH to 7. This analytical method has been utilized to study the effect of sodium bicarbonate administration on the excretion of salicylate during aspirin therapy for acute rheumatic fever. It is the main pathway of metabolism for salicylic acid and is rapidly excreted by the kidney. The rate of elimination can vary from person to person and is influenced by factors like liver function, hydration, and other medications. Salicylate, an active form of aspirin, is widely distributed in the body, metabolized mainly in the liver by conjugation, and excreted in the urine mostly as salicyluric acid. . Mar 17, 2025 · Salicylic Acid package insert / prescribing information for healthcare professionals. Salicylic acid shows a trough at 292 nm and a satellite peak at 316 nm in the second-derivative spectrum. zrbjo74 vq uio x4zly0 na2sk e3w jq jflvv8 xe5i rl0j8s